Cholyl-iFluor™647缀合物

	货号	36703	存储条件	在零下15度以下保存, 避免光照
	规格	1 mg	价格	3732
	Ex (nm)	656	Em (nm)	670
	分子量	1289.57	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：36703

产品名称：Cholyl-iFluor™647缀合物

规格：1 mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：1289.57

外观：固体

溶剂：DMSO

Ex(nm):656

Em(nm):670

产品介绍

Cholyl-iFluor™647缀合物是我们绿色荧光Cholyl-Lys-Fluorescein（＃36701）的红色荧光类似物。它是iFluor™647标记的胆汁酸衍生物，与胆酸衍生物的细胞结合和摄取特性极为相似。它是一种二价的“单极性”阴离子荧光一羟基胆汁盐类似物，其物理，生物学和胆汁抑制特性与石胆酸盐，乙醇胆酸及其衍生物相似，因此是研究单羟基胆汁盐引起的胆汁淤积的机制的优质探针。

参考文献

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L-arginine conjugates of bile acids-a possible treatment for non-alcoholic fatty liver disease.
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Journal: Lipids in health and disease (2014): 69

The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease.
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Amino acid-bile acid based molecules: extremely narrow surfactant nanotubes formed by a phenylalanine-substituted cholic acid.
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Journal: Chemical communications (Cambridge, England) (2012): 12011-3

Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic.
Authors: Leikin-Frenkel, Alicia and Gonen, Ayelet and Shaish, Aviv and Goldiner, Ilana and Leikin-Gobbi, Diana and Konikoff, Fred M and Harats, Dror and Gilat, Tuvia
Journal: Archives of medical research (2010): 397-404

Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice.
Authors: Leikin-Frenkel, Alicia and Parini, Paolo and Konikoff, Fred M and Benthin, Lisbet and Leikin-Gobbi, Diana and Goldiner, Ilana and Einarsson, Curt and Gilat, Tuvia
Journal: Archives of biochemistry and biophysics (2008): 63-71

Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents.
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[Innovations in the medical treatment of gallstones and fatty liver: FABACs (Fatty Acid Bile Acid Conjugates)].
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ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid-bile acid conjugates (FABACs).
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New targets in and potential treatments for cholesterol gallstone disease.
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